Patrick Mahomes threw for 428 yards and five touchdowns, two to Jakeem Grant, to lead Texas Tech past Iowa State 66-31 on Saturday for the Red Raiders' first Big 12 win.
Grant had a career-high 166 yards on nine catches. He caught TD passes of 75 and 37 yards for Texas Tech (4-2, 1-2). It was Grant's third 100-plus-yard game this season.
DeAndre Washington had a receiving and a rushing TD, while Justin Stockton scored on a 54-yard rush.
The Red Raiders intercepted Cyclones quarterback Sam Richardson three times -- two by J.J. Gaines -- and Texas Tech scored touchdowns off two of them.
Mahomes was sacked for only the second time this season when he was called for intentional grounding.
Redshirt freshman Mike Warren had his third straight game of more than 100 yards for the Cyclones (2-3, 1-1), finishing with a career-high 245 yards on 23 carries.
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